Magnetothermal Modulation of Calcium?Dependent Nerve Growth

Nerve injuries are common, and the available treatments including invasive surgeries do not guarantee complete regeneration of injured nerves restoration function. Despite ability peripheral to regenerate, slow rate axonal growth hampers functional recovery. Development new approaches discover underlying mechanisms that may accelerate is needed overcome these limitations augment nerve injury. In addition chemical factors, recent studies suggested use optogenetics electrical stimulation promote growth. The approaches, however, require further investigation. Furthermore, their application relies on hardware, which be compatible with under significant mechanical deformation. Here, it shown thermal activation a heat sensitive ion channel TRPV1 promotes in calcium-dependent manner. By leveraging dissipation magnetic nanoparticles alternating fields, calcium influx through channels endogenously expressed dorsal root ganglion explants triggered remotely. accelerated elongation neurofilaments increased Schwann cell migration following magnetothermal observed. These findings suggest future applications modulation as minimally approach regeneration.